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Susanne Schneiker-Bekel Selected Research

Acarbose

11/2020The expression of the acarbose biosynthesis gene cluster in Actinoplanes sp. SE50/110 is dependent on the growth phase.
11/2020A maltose-regulated large genomic region is activated by the transcriptional regulator MalT in Actinoplanes sp. SE50/110.
6/2020Absence of the highly expressed small carbohydrate-binding protein Cgt improves the acarbose formation in Actinoplanes sp. SE50/110.
6/2017Genome improvement of the acarbose producer Actinoplanes sp. SE50/110 and annotation refinement based on RNA-seq analysis.
1/2017The MalR type regulator AcrC is a transcriptional repressor of acarbose biosynthetic genes in Actinoplanes sp. SE50/110.
8/2016Genetic engineering in Actinoplanes sp. SE50/110 - development of an intergeneric conjugation system for the introduction of actinophage-based integrative vectors.
1/2016Comparative proteome analysis of Actinoplanes sp. SE50/110 grown with maltose or glucose shows minor differences for acarbose biosynthesis proteins but major differences for saccharide transporters.
7/2015Comprehensive proteome analysis of Actinoplanes sp. SE50/110 highlighting the location of proteins encoded by the acarbose and the pyochelin biosynthesis gene cluster.
12/2014Carbon source dependent biosynthesis of acarviose metabolites in Actinoplanes sp. SE50/110.
11/2014Improving the genome annotation of the acarbose producer Actinoplanes sp. SE50/110 by sequencing enriched 5'-ends of primary transcripts.

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Susanne Schneiker-Bekel Research Topics

Disease

6Type 2 Diabetes Mellitus (MODY)
06/2017 - 12/2014
4Diabetes Mellitus
11/2020 - 11/2014
1Meningococcal Infections
09/2012

Drug/Important Bio-Agent (IBA)

10AcarboseFDA LinkGeneric
11/2020 - 11/2014
4Pharmaceutical PreparationsIBA
11/2020 - 11/2014
3GlucosidasesIBA
06/2020 - 07/2015
2CarbonIBA
01/2016 - 12/2014
2Glucose (Dextrose)FDA LinkGeneric
01/2016 - 12/2014
2MaltoseIBA
01/2016 - 12/2014
1Galactose (Galactopyranose)FDA LinkGeneric
12/2014
1Glycoside Hydrolase InhibitorsIBA
11/2014
1Polysaccharides (Glycans)IBA
09/2012